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CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF

Application US20260078111A1 Kind: A1 Mar 19, 2026

Assignee

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Inventors

Mark C. SIRACUSA, Jacques Y. ROBERGE, John A. GILLERAN, John PIWINSKI

Abstract

Provided herein are novel compounds, such as a compound of Formula I or Formula A: or a salt thereof, wherein R1-R3, L1, R10, ring A and ring B have any of the values described in the specification, as well as compositions comprising the novel compounds herein. The compounds are typically carbonic anhydrase inhibitors and are useful for the prophylactic or therapeutic treatment of a disease or condition mediated by a carbonic anhydrase enzyme.

CPC Classifications

C07D 413/10 A61K 31/404 A61K 31/4178 A61K 31/4439 A61K 31/454 A61K 31/4709 A61K 31/4725 A61K 31/496 A61K 31/5377 A61P 37/08 C07D 209/34 C07D 401/04 C07D 401/06 C07D 401/10 C07D 403/10 C07D 405/04 C07D 405/06

Filing Date

2023-12-07

Application No.

19130641