CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF
Application
US20260078111A1
Kind: A1
Mar 19, 2026
Assignee
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Inventors
Mark C. SIRACUSA, Jacques Y. ROBERGE, John A. GILLERAN, John PIWINSKI
Abstract
Provided herein are novel compounds, such as a compound of Formula I or Formula A: or a salt thereof, wherein R1-R3, L1, R10, ring A and ring B have any of the values described in the specification, as well as compositions comprising the novel compounds herein. The compounds are typically carbonic anhydrase inhibitors and are useful for the prophylactic or therapeutic treatment of a disease or condition mediated by a carbonic anhydrase enzyme.
CPC Classifications
C07D 413/10
A61K 31/404
A61K 31/4178
A61K 31/4439
A61K 31/454
A61K 31/4709
A61K 31/4725
A61K 31/496
A61K 31/5377
A61P 37/08
C07D 209/34
C07D 401/04
C07D 401/06
C07D 401/10
C07D 403/10
C07D 405/04
C07D 405/06
Filing Date
2023-12-07
Application No.
19130641