ISOQUINOLONES AS PI3K INHIBITORS
Application
US20260078103A1
Kind: A1
Mar 19, 2026
Assignee
OnKure, Inc.
Inventors
James F. BLAKE, Mark Laurence BOYS, David A. MARESKA, Joshua Nathaniel PAYETTE, Christie A. SCHULTE, Bryan YESTREPSKY, Qian ZHAO
Abstract
Novel PI3K inhibitors of the general formula (1) are described along with methods of their preparation and their use in the treatment of diseases associated with the elevation or activation of the PI3K pathway, wherein R1 to R8 are as defined.
CPC Classifications
C07D 401/04
A61K 31/4725
A61K 31/496
A61K 31/497
A61K 31/4985
A61K 31/4995
A61K 31/501
A61K 31/506
A61K 31/519
A61K 31/5377
A61K 31/541
A61K 31/675
C07D 217/24
C07D 401/12
C07D 401/14
C07D 405/04
C07D 405/14
C07D 413/04
C07D 413/14
C07D 417/04
C07D 417/14
C07D 451/02
C07D 471/04
C07D 471/08
C07D 471/10
C07D 487/04
C07D 487/08
C07D 487/10
C07D 491/048
C07D 491/107
C07D 498/04
C07D 513/04
C07F 9/6584
Filing Date
2023-09-06
Application No.
19107476