NEUROTENSIN RECEPTOR LIGANDS

Abstract

The present invention is related to a compound of formula (I): whereinR1 is selected from the group consisting of hydrogen, methyl and cyclopropylmethyl;AA-COOH is an amino acid selected from the group consisting of 2-amino-2-adamantane carboxylic acid, cyclohexylglycine and 9-amino-bicyclo[3.3.1]nonane-9-carboxylic acid;R2 is selected from the group consisting of (C1-C6)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkylmethyl, halogen, nitro and trifluoromethyl;ALK is (C2-C5)alkylidene;R3, R4 and R5 are each and independently selected from the group consisting of hydrogen and (C1-C4)alkyl under the proviso that one of R3, R4 and R5 is of the following formula (II) whereinALK′ is (C2-C5)alkylidene;R6 is selected from the group consisting of hydrogen and (C1-C4)alkyl; andR7 is selected from the group consisting of H and an Effector moiety;or a pharmacologically acceptable salt, solvate or hydrate thereof.

CPC Classifications