COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
Application
US20260078082A1
Kind: A1
Mar 19, 2026
Inventors
Kerry E. BENENATO, Mark CORNEBISE
Abstract
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
CPC Classifications
C07C 229/12
A61K 9/0019
A61K 9/0043
A61K 9/0073
A61K 9/127
A61K 9/1272
A61K 9/1617
A61K 9/1641
A61K 9/5123
A61K 9/5146
A61K 31/7105
A61K 38/1725
A61K 38/1816
A61K 47/543
A61K 47/6911
A61K 48/0033
A61K 48/005
C07C 227/16
C07C 227/18
C07C 229/16
C07C 233/36
C07C 233/72
C07C 235/10
C07C 255/24
C07C 263/20
C07C 271/20
C07C 275/14
C07C 279/12
C07C 279/24
C07C 279/28
C07C 279/32
C07C 311/05
C07C 335/08
C07D 207/27
C07D 233/72
C07D 249/04
C07D 263/20
C07D 265/33
C07D 271/06
C07D 271/10
C07D 277/38
C07F 9/091
C07K 14/505
A61K 9/1271
A61K 48/00
C07C 2601/02
C07C 2601/04
C07C 2601/14
C07C 2601/18
Filing Date
2025-07-21
Application No.
19275692