MICRONEEDLE DRUG DELIVERY APPARATUS AND PREPARATION METHOD THEREOF

Abstract

The present application relates to the technical field of drug delivery, and particularly, to a microneedle drug delivery apparatus and a preparation method thereof. The apparatus includes: a substrate; an array of microneedles loaded on the substrate; and a liquid-absorbing swellable material wrapped by the substrate to form a closed sandwich structure. This microneedle drug delivery apparatus allows microneedles to penetrate an intestinal wall using a mild water-absorbing swellable mechanism and natural peristaltic behavior of a gastrointestinal tract, to complete drug delivery. It penetrates a physiological barrier of oral delivery and absorption of biologic drugs by physical means, improving oral bioavailability of biologic drugs. Also, all materials used are biodegradable soft materials, with high safety.

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