Medicament-Coated Balloon Coating Solution, Coating Material, Medicament-Coated Balloon, Preparation Method Therefor, and Use Thereof

Abstract

Provided are a medicament-coated balloon coating solution, a coating material, a medicament-coated balloon, a preparation method therefor, and use thereof. The medicament-coated balloon coating solution comprises an aqueous-phase solvent. The coating solution further comprises a plurality of core-shell structures formed by wrapping a medicament in a phospholipid bilayer. The core-shell structures are dispersed in the aqueous-phase solvent. A core of each core-shell structure comprises a plurality of particles loaded with the medicament. A shell of each core-shell structure is the phospholipid bilayer. The phospholipid bilayer comprises a hydrophilic group in an outer layer and a hydrophobic group in an inner layer. The plurality of particles loaded with the medicament comprise a plurality of nanocrystalline particles comprising the medicament. Nanocrystalline is combined with liposome, such that advantages of two types of medicament carriers are combined. The formed phospholipid bilayer increases the solubility of a poorly soluble medicament on the medicament-coated balloon, the medicament loading capacity is high, the stability of the medicament carriers is good, and the medicament crystal form is stable, such that the medicament release rate is controllable.

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