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Methods of Treating or Preventing Amyotrophic Lateral Sclerosis

Application US20260077060A1 Kind: A1 Mar 19, 2026

Assignee

Rowan University

Inventors

Jeremy Francis, Paola Leone

Abstract

This disclosure provides methods for treating, ameliorating, or reversing at least one symptom of amyotrophic lateral sclerosis (ALS) in a subject by increasing the amount of neuronal aspartate in spinal cord through administration of a therapeutically effective amount of a composition comprising a nucleic acid encoding ASPA or a functional fragment thereof.

CPC Classifications

A61K 48/005 C12N 15/86 C12N 2750/14143 C12N 2750/14171 C12Y 305/01015

Filing Date

2025-11-21

Application No.

19396542