PEPTIDE-TYPE NUCLEIC ACID CARRIER, GENE THERAPEUTIC COMPOSITION INCLUDING IT AND USE THEREOF

Abstract

Provided in the present invention is a peptide-type nucleic acid carrier, a gene therapeutic composition including it and a use thereof, wherein the peptide-type nucleic acid carrier comprises one or multiple copolypeptide chains comprising: a hydrophilic peptide segment and a hydrophobic peptide segment disposed at C-terminus of the hydrophilic peptide segment. The hydrophilic peptide segment is consisted of a plurality of positively charged amino acids. With the positively charge, the hydrophilic peptide segment attracts nuclear fragments and form a copolypeptide-nucleic acid complex, enabling nuclear fragments' delivery to target cells. On the other hand, the hydrophobic peptide segment protects the nuclear fragments from degradation by circulatory enzymes or intracellular endosome, thereby enhancing transfection efficiency. In light of this, the present invention provides an innovative means of gene therapy.

CPC Classifications