COMPOUNDS FOR THE DEGRADATION OF EGFR KINASE
Application
US20260077051A1
Kind: A1
Mar 19, 2026
Assignee
BeOne Medicines I GmbH
Inventors
Huaqing LIU, Bailin LEI, Yizhou ZHAO, Jia TANG, Shaohan LIAO, Zhiwei WANG
Abstract
Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
CPC Classifications
A61K 47/55
A61K 47/545
C07D 498/22
Filing Date
2025-11-26
Application No.
19402615