CATIONIC LIPID BASED COMPOSITION, FORMULATION AND USE FOR NUCLEIC ACID VACCINE DELIVERY AND PREPARATION THEREOF
Assignee
BHARAT BIOTECH INTERNATIONAL LIMITED
Inventors
Namita Santosh MAHADIK, Bhattacharyya TITHI, Bhowmira RATHORE, Pooja POTDAR, Immanuel CHRISTIANA, Sabarinadh CHILAKA, Sai Balaji ANDUGULAPATI, Ramakrishna SISTLA, Rajkumar BANERJEE, Krishna Murthy ELLA, D. Yogeswara RAO
Abstract
The present invention discloses a cationic lipid-based formulation for in vivo delivery of nucleic acid. The present invention describes the development of a lipid system that can induce efficient non-viral delivery of nucleic acid. especially RNA. for the purpose of efficient nucleic acid transfection toward eliciting vaccination in vivo. Present invention provides a lipid/RNA complex (lipoplex) formulation having sufficiently long shelf life that performs without any compromise in its transfection output. The present invention further provides cationic lipid-based formulations for RNA delivery with maximum nucleic acid complexation ability and with comparatively lesser amount of cationic lipid having higher stability.
CPC Classifications
Filing Date
2023-06-22
Application No.
18881055