ADRENOMEDULLIN ANALOGS AND METHODS OF USE THEREOF

Abstract

Adrenomedullin (ADM) is shown to be protective against damage to neurons as a result of hypoxic brain injuries, radiation brain injuries, and to prevent neurodevelopmental injury in encephalopathy of prematurity; 22q11.2 deletion syndrome, e.g. DiGeorge Syndrome; and other neurologic diseases associated with mitochondrial dysfunction. Modified ADM peptides are provided, which are stabilized relative to the native peptide. In an embodiment, a therapeutic composition is provided, comprising an ADM analog of the disclosure, and a pharmaceutically acceptable excipient. In an embodiment, a method is provided for treating or preventing neurologic damage in an individual, the method comprising administering an effective dose of ADM.

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