NOVEL COMPOSITION COMPRISING ANTIBODIES
Application
US20260077016A1
Kind: A1
Mar 19, 2026
Inventors
Jan JEZEK, David GERRING
Abstract
An aqueous solution composition of pH in the range 4.0-8.5 comprising: an antibody construct comprising an Fc domain;optionally one or more buffers being substances having at least one ionisable group with a pKa in the range 3.0 to 9.5 and which pKa is within 2 pH units of the pH of the composition;optionally one or more neutral amino acids; andan uncharged tonicity modifier; wherein the buffers are present in the composition at a total concentration of 0-5 mM; and wherein the total ionic strength of the composition excluding the contribution of the engineered protein construct is less than 20 mM.
CPC Classifications
A61K 38/1774
A61K 38/1793
A61K 38/191
A61K 47/02
A61K 47/10
A61K 47/12
A61K 47/183
A61K 47/26
C07K 14/70532
C07K 14/71
C07K 14/7151
Filing Date
2025-11-20
Application No.
19395382