INTEGRIN INHIBITORS AS THERAPY FOR OBESITY DISORDERS

Abstract

Methods for inhibiting or preventing activation of a macrophage, by a receptor antagonist of α9β1 integrin are provided. Further provided are methods for treating or preventing an inflammatory disease or a metabolic disorder, including a metabolic syndrome, in a subject in need thereof, and a pharmaceutical composition comprising a peptide comprising the amino acid sequence: EDDMMEVPY, for use in treatment or prevention of an inflammatory disease or a disorder, in a subject in need thereof.

CPC Classifications