ONCOLYTIC VIRUS EXPRESSING AN IMMUNE CELL ENGAGER FOR TUMOR TARGETING
Application
US20260077006A1
Kind: A1
Mar 19, 2026
Inventors
Xiaohu Liu, I-Fang Lee, Yanal M. Murad
Abstract
An HSV vector with an expression cassette encoding an immune cell engager protein under control of an EF1α promoter. ICP27 under control of a CEA promoter. ICP34.5 under control of miRNA-124/143, and ICP47 under control of a ICP27 promoter is disclosed. The HSV vector also includes deletion of one copy of terminal repeat long region and one copy of terminal repeat short region. The immune cell engager protein comprises a T-cell binding domain and a tumor-associated antigen binding domain.
CPC Classifications
A61K 35/763
A61P 35/00
C07K 14/005
C07K 16/2803
C07K 16/2809
C07K 16/2818
C07K 16/2827
C07K 16/2875
C07K 16/2878
C07K 16/3092
C12N 7/00
C12N 15/1133
C07K 2317/31
C07K 2317/569
C07K 2317/622
C12N 2310/141
C12N 2710/16621
C12N 2710/16622
C12N 2710/16632
Filing Date
2023-09-08
Application No.
19110072