COMPOSITIONS AND METHODS FOR TREATMENT OF CARDIAC DISORDERS
Application
US20260077004A1
Kind: A1
Mar 19, 2026
Assignee
University of Massachusetts
Inventors
Kevin Donahue, Phillip Tai, Guangping Gao
Abstract
Some aspects of the disclosure provide truncated potassium voltage-gated channel subfamily H member 2 (KCNH2) proteins. In some aspects, the disclosure provides nucleic acid regulatory elements comprising (i) an atrial natriuretic peptide (Anf) promoter and (ii) an enhancer element, wherein the enhancer element is not a naturally-occurring Anf enhancer element.
CPC Classifications
A61K 35/76
A61K 48/0058
C07K 14/005
C07K 14/705
C12N 15/86
A61K 38/00
C12N 2750/14143
C12N 2830/008
Filing Date
2025-06-25
Application No.
19248947