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HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT OR AMELIORATION OF CANCER

Application US20260076967A1 Kind: A1 Mar 19, 2026

Assignee

Tolremo Therapeutics AG

Inventors

Stefanie Flückiger-Mangual, Dorothea Gruber, Rutger Folmer, Koen F.W. Hekking, Johan J.N. Veerman, Martijn Eerland, Charles-Henry Fabritius

Abstract

The present invention relates to a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof: formula (I) and to pharmaceutical compositions comprising a compound of formula (I), as well as to the use of a compound of formula (I), or a pharmaceutically acceptable salt, solvate, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, in the treatment of cancer. Further aspects of the present invention include combination therapies in which a compound of formula (I), as well as to the use of a compound of formula (I), or a pharmaceutically acceptable salt, solvate, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, is used in combination with a known anti-cancer agent.

CPC Classifications

A61K 31/506 A61K 31/517 A61K 31/53 A61K 31/5377 A61K 31/5386 A61K 31/69 A61K 45/06 A61P 35/00 C07D 401/14 C07D 405/14 C07D 409/14 C07D 413/14 C07D 471/04 C07D 498/08 C07F 5/027 C07B 2200/05 C07B 2200/07 C07B 2200/09 C07B 2200/13

Filing Date

2025-09-23

Application No.

19336888