METHOD FOR IMPROVING SKELETAL HEALTH

Abstract

The present disclosure relates to an alternative intervention to improve skeletal muscle health in chronic kidney disease (CKD). CKD causes skeletal muscle complications that lead to increased risk of falls, hospitalizations and mortality. While exercise is a common treatment for these impairments in the general population, in patients with CKD exercise has shown only marginal improvements in aerobic capacity and inconsistent effects on muscle strength, walking distance, and timed-up-and-go tests indicating this ‘usual’ treatment is not enough in patients in CKD. The present disclosure relates to methods of using an aminoindazole to treat inflammation and metabolic derangements and to improve skeletal muscle health in CKD.

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