COMPOSITION AND PROCESS FOR A LIPID NANO-PARTICLE DELIVERY OF OXYGEN AND VITAL METABOLIC COMPOUNDS FOR HEMORRHAGIC SHOCK

Abstract

Generation of lipid nano-particles containing purified human hemoglobin as an oxygen carrier was accomplished with the co-encapsulation of metabolic agents. Additionally, the nano-particles described are of the long-circulating variety (Pegylation of the exterior surface) which are more tolerable in vivo when compared against their non-pegylated counterparts. The generated nano-particles are lyophilizable, given proper formulation with lyo-protectants, which are storage stable solids ready for reconstitution prior to use.

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