PHARMACEUTICAL COMPOSITIONS AND METHODS

Abstract

Described is an extended release pharmaceutical composition. The composition comprises a therapeutically effective amount of an active agent selected from the group consisting of ketamine, norketamine, pharmaceutically acceptable salts thereof, and combinations thereof. The active agent is incorporated into a sustained-release polymeric matrix. The matrix comprises a matrix polymer, and a permeability-modifying filler. A method of preventing, treating and/or managing treatment-resistant depression in a subject is also or alternatively describe.

CPC Classifications