Complexation of Oxybenzone with C-methylresorcin[4]arene

Abstract

The present invention involves the formation of host-guest complexes between C-methylresorcin[4]arene and Oxybenzone (OXB). NMR spectroscopy confirmed the formation of a weak host-guest complex and molecular dynamics docking simulations indicated that this complex likely had a 1:1 stoichiometry. Furthermore, skin permeation testing revealed that complexation by C-methylresorcin[4]arene significantly reduced the amount of OXB that permeated skin. These results show the potential of supramolecular complexation for improving the stability and decreasing the skin permeability of OXB, thus limiting harmful side effects.

CPC Classifications