Method and Device for Whole Organ Pulsed Electric Field Application for Irreversible Electroporation

Abstract

An exemplary pulsed electric field system and method that can uniformly emit electrical pulses via use of a conductivity-controlled liquid medium to penetrate a pre-defined depth of a target tissue for a whole or region of a hollow or tubular organ to induce a tissue response. The conductivity-controlled liquid medium allows more uniform electrical pulses to be generated with less localized or focal bursts of pulses, which can reduce the required power rating of the electric generator for the pulses. The pulsed electric field system and method can be used for irreversible electroporation and subsequent exfoliation of the surface tissue, electroporation, pulsed field ablation, or cell stimulation.

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