METHOD FOR PROMOTING GENERATION OF MICROVESICLES CONTAINING MITOCHONDRIA AND MEDICAL USE THEREOF
Applicants
KingBios Co., Ltd.
Inventors
WANG, Yi-Chuang
Abstract
A method for promoting generation of a mitochondria-containing microvesicle and a pharmaceutical use thereof. Specifically, provided is a use of a combination of a mitochondrial generation promoting factor and an extracellular vesicle generation promoting factor, for use in promoting generation of the mitochondria-containing microvesicle. Also provided is a method for generating an extracellular vesicle composition: co-culturing a cell having mitochondria with the mitochondrial generation promoting factor and the extracellular vesicle generation promoting factor to obtain the extracellular vesicle composition rich in the mitochondria-containing microvesicle. Adding the above factors may promote the cell to generate the mitochondria-containing microvesicle. The collected mitochondria are encapsulated by the microvesicle, and therefore can be easily stored and transferred into the cell. Also provided are an isolated extracellular vesicle composition, a pharmaceutical composition comprising the same, and a use thereof in preparing a medicine for treating diabetes and/or renal injury.
IPC Classifications
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR