← EPO Patent Bulletin

FUSED PYRROLE RING OR FUSED PYRIDINE RING COMPOUND

Publication EP4711364A1 Kind: A1 Mar 18, 2026

Applicants

Pharmaengine, Inc.

Inventors

LIU, Cheng-Hao, LIN, Long-Zhi, WANG, Hong-Ren, XUN, Guoliang, SUN, Yina, YANG, Jinyu, ZHOU, Jianlai, CHEN, Bin

Abstract

The present disclosure provides a compound of formula (I): wherein ring A, Z1, Z2, Z3, Z4, Z5, Z6, Z7, X, R1, R2, R3, R4, R5, R6, and n are as disclosed in the specification. The compound of formula (I) is for use as a Myt1 inhibitor. The present disclosure also provides a pharmaceutical composition comprising the compound of formula (I) and a method of treating cancer using the compound. The present disclosure further provides a process for preparing the compound of formula (I).

IPC Classifications

C07D 471/04 20060101AFI20241122BHEP C07D 487/00 20060101ALI20241122BHEP C07D 519/00 20060101ALI20241122BHEP A61K 31/395 20060101ALI20241122BHEP A61P 35/00 20060101ALI20241122BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR