IMPROVED SYNTHESIS OF KRAS G12C INHIBITOR COMPOUND
Search Report
EP4700030A3
Kind: A3
Mar 18, 2026
Applicants
AMGEN, INC.
Inventors
PARSONS, Andrew T., BEAVER, Matthew
Abstract
The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2,2',2"-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-fluorophenol), useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
IPC Classifications
C07D 471/04 20060101AFI20260206BHEP
C07F 5/05 20060101ALI20260206BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR