METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF
Applicants
Madrigal Pharmaceuticals, Inc., F. Hoffmann-La Roche Ltd
Inventors
HESTER, Keith D., DUGUID, Robert J., KELLY, Martha, CHASNOFF, Anna, DONG, Gang, CROW, Edwin L., TAUB, Rebecca, REYNOLDS, Charles H., CHOI, Duk Soon, SHU, Lianhe, WANG, Ping
Abstract
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRP mutation.
IPC Classifications
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR