MOLECULES FOR USE TO TREAT OR PREVENT CARDIAC DISEASES
Applicants
Universiteit Gent, HOWEST, de Hogeschool West-Vlaanderen
Inventors
LEYBAERT, Luc, LISSONI, Alessio, HULPIAU, Paco, DE SMET, Maarten
Abstract
The present invention relates to the treatment or prevention of certain cardiac diseases by targeting interactions between the ryanodine type-2 receptor (RyR2) protein and the connexin 43 (Cx43) protein. Indeed, the present invention relates to molecules -more specifically peptides- which target an FDFPDDN-containing interaction domain on the connexin 43 (Cx43) protein or which target an KNRRNPRL-containing interaction domain on the ryanodine type-2 receptor (RyR) protein, and which inhibit the opening of connexin 43 (Cx43) hemichannels present in cardiomyocytes. Hence, the latter molecules are useful to treat or prevent cardiac diseases in which the opening of Cx43 hemichannels is pathogenic.
IPC Classifications
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR