COMPLETELY HUMANIZED MONOCLONAL NEUTRALIZING ANTIBODY FOR TETANUS TOXIN AND APPLICATION THEREOF
Applicants
Zhuhai Trinomab Pharmaceutical Co., Ltd.
Inventors
LIAO, Huaxin, WANG, Yueming, YUAN, Xiaohui, ZHENG, Weihong
Abstract
The invention describes fully native human neutralizing monoclonalantibodies against tetanus toxin. The invention developed fully native human neutralizing monoclonalantibodies against tetanus toxin through a systematic high through-put platform that is specialized for identifying and developing human native antibody. The neutralizing monoclonal antibodies described in the invention can be used in the prevention, treatment and testing ofClostridium tetaniinfection. The fully human neutralizing monoclonal antibodies developed in the invention have a high affinity toward tetanus toxin, as well as pocessessing high neutralizing activities against the toxin, safe of use with high disease prevention effectiveness, free of exogenous virus contamination, and are widely applicable to various human groups with strong industrial applications.
IPC Classifications
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR