NOVEL METHOD FOR PRODUCING ANTIBODY-DRUG CONJUGATE
Publication
EP3677568A1
Kind: A1
Mar 18, 2026
Applicants
Daiichi Sankyo Company, Limited
Inventors
NISHI Yoshio, SAKANISHI Kohei, NOGUCHI Shigeru, TAKEDA Tadahiro
Abstract
A method for producing a compound represented by formula (C) wherein R<sup>1</sup>represents an amino group protected with a protecting group, the method comprising a step of subjecting a compound represented by formula (B) wherein R<sup>1</sup>represents the same meaning as above, to intramolecular cyclization to convert the compound into the compound represented by formula (C).
IPC Classifications
C07C 231/12 20060101AFI20210408BHEP
A61K 31/4745 20060101ALI20210408BHEP
A61K 39/395 20060101ALI20210408BHEP
A61K 47/68 20170101ALI20210408BHEP
A61P 35/00 20060101ALI20210408BHEP
C07C 233/15 20060101ALI20210408BHEP
C07C 233/33 20060101ALI20210408BHEP
C07C 233/54 20060101ALI20210408BHEP
C07D 491/22 20060101ALI20210408BHEP
C07K 7/06 20060101ALI20210408BHEP
C07K 16/00 20060101ALI20210408BHEP
C07K 16/28 20060101ALI20210408BHEP
C07B 61/00 20060101ALI20210408BHEP
C07C 201/12 20060101ALI20210408BHEP
C07C 209/36 20060101ALI20210408BHEP
C07C 231/02 20060101ALI20210408BHEP
C07C 233/43 20060101ALI20210408BHEP
C07C 211/56 20060101ALI20210408BHEP
C07C 205/12 20060101ALI20210408BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR