METHOD OF DIRECTED DIFFERENTIATION PRODUCING CORNEAL ENDOTHELIAL CELLS, COMPOSITIONS THEREOF, AND USES THEREOF
Publication
EP3517604A1
Kind: A1
Mar 18, 2026
Applicants
Astellas Institute for Regenerative Medicine
Inventors
MCCABE, Kathryn L., LU, Shi-Jiang, LANZA, Robert
Abstract
This disclosure generally relates to cell-based therapies for treatment of visual disorders, including disorders of the cornea. Methods are exemplified for directed differentiation of corneal cells from stem cells. Compositions of corneal endothelial cells and uses thereof are also provided. Exemplary compositions exhibit improved cell density and/or more "youthful" gene expression relative to cells obtained from donated tissue.
IPC Classifications
C12N 5/071 20100101AFI20190415BHEP
A61L 27/38 20060101ALI20190415BHEP
A61K 35/12 20150101ALI20190415BHEP
A61K 45/06 20060101ALI20190415BHEP
A61K 9/00 20060101ALI20190415BHEP
A61K 35/30 20150101ALI20190415BHEP
C12N 5/079 20100101ALI20190415BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR