A FUSION PEPTIDE COMPRISING GLP-2 AND ELASTIN-LIKE PEPTIDES
Publication
EP3412300A1
Kind: A1
Mar 18, 2026
Applicants
Duke University
Inventors
CHILKOTI, Ashutosh
Abstract
The present invention provides therapeutic agents and compositions comprising elastin-like peptides(ELPs) and therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistence in the body, solubility, and bioavailability.
IPC Classifications
A61K 38/26 20060101AFI20260121BHEP
C07K 14/78 20060101ALI20260121BHEP
C07K 1/00 20060101ALI20260121BHEP
Designated States
AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR