PROTEIN AQUEOUS SUSPENSION

Publication EP3064213A1 Kind: A1 Mar 18, 2026

Applicants

Terumo Kabushiki Kaisha

Inventors

IZAKI Shunsuke, KIMOTO Tomoaki, HANDA Kenji, MIEDA Shiuhei, SHIRAKI Kentaro, KURINOMARU Takaaki, MARUYAMA Takuya

Abstract

It is an object of the present invention to provide, for a wide range of proteins, an aqueous suspension preparation containing a protein complex that can be concentrated and is high in stability. The present invention is an aqueous suspension preparation comprising an aqueous suspension in which a protein and a polyamino acid that have surface charge in a buffer form a complex to be suspended in the buffer, wherein the protein can be concentrated by removing at least part of water from the complex-containing aqueous suspension, and in the complex, the protein has at least one of shaking stress resistance, fluidity enhancement, oxidation resistance, thermal stability, and aggregation inhibitory properties.

IPC Classifications

A61K 38/00 20060101AFI20251002BHEP A61K 9/08 20060101ALI20251002BHEP A61K 9/10 20060101ALI20251002BHEP A61K 38/22 20060101ALI20251002BHEP A61K 38/43 20060101ALI20251002BHEP A61K 39/395 20060101ALI20251002BHEP A61K 47/12 20060101ALI20251002BHEP A61K 47/34 20060101ALI20251002BHEP C07K 1/00 20060101ALI20251002BHEP C07K 14/52 20060101ALI20251002BHEP C07K 14/575 20060101ALI20251002BHEP C07K 16/00 20060101ALI20251002BHEP C07K 19/00 20060101ALI20251002BHEP C12N 9/00 20060101ALI20251002BHEP A61P 43/00 20060101ALI20251002BHEP A61P 5/00 20060101ALI20251002BHEP A61K 38/50 20060101ALI20251002BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

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